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Royal Maladies: Inherited Diseases in the Ruling Houses of Europe Alan R. Rushton

Royal Maladies: Inherited Diseases in the Ruling Houses of Europe

Alan R. Rushton

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Kindle Edition
276 pages
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An intensive historical study of the hereditary diseaseshemophilia and porphyria in the personal and political lives of the European royalfamiliesPart INineteenth century medical knowledgeof hemophilia as a hereditary bleeding disorder will beMoreAn intensive historical study of the hereditary diseaseshemophilia and porphyria in the personal and political lives of the European royalfamiliesPart INineteenth century medical knowledgeof hemophilia as a hereditary bleeding disorder will be considered.Hemophilia appeared in a son born to Queen Victoria in 1853.Hemophilia wastransmitted through Victoria’s unaffected daughters to the ruling houses inGermany, Russia and Spain.The political consequences of a chronically illmale heir to the throne fostered the demise of the royal families in thesecountries.The royal physicians were well aware of the hereditary nature ofhemophilia and failed to advise the British royal family on this matter that hadsignificant political consequences for the modern world.Part IIThe “Madness of King GeorgeIII” resulted from variegate porphyria, an inherited disorder of hememetabolism.The disorder was evident in:The immediate family ofGeorge III, Ancestors from at least the 13th century, Descendents into the 20th century.The malady was inherited by other ruling houses in continental Europe and affectedpolitical life there for over six centuries.Genetic analysis will considerhow such an anomaly could have been inherited through so many successivegenerations.Preliminary DNA evidence will be considered to documentvariegate porphyria in living relatives of the British royal family.Alternate history if these disorders had not plagued the royal families will beconsidered in conclusion.